A brilliant but unhinged scientist finally encounters the mysterious Spider-Girl, a creature feared for her agility and venomous strength. She approaches him with confidence, believing her webbing and superhuman reflexes will make this an easy victory. But the scientist has been preparing for this moment—he has discovered a chemical formula that suppresses her arachnid abilities.

As her powers fade, Spider-Girl struggles to resist, realizing too late that she underestimated her opponent. The scientist, now triumphant, captures her and drags her back to his secret laboratory, where he plans to use her as the subject of his next, dangerous experiments.